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Proceedings Paper

Lung vasculature imaging using speckle variance optical coherence tomography
Author(s): Michelle Cua; Anthony M. D. Lee; Pierre M. Lane; Annette McWilliams; Tawimas Shaipanich; Calum E. MacAulay; Victor X. D. Yang; Stephen Lam
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Paper Abstract

Architectural changes in and remodeling of the bronchial and pulmonary vasculature are important pathways in diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. However, there is a lack of methods that can find and examine small bronchial vasculature in vivo. Structural lung airway imaging using optical coherence tomography (OCT) has previously been shown to be of great utility in examining bronchial lesions during lung cancer screening under the guidance of autofluorescence bronchoscopy. Using a fiber optic endoscopic OCT probe, we acquire OCT images from in vivo human subjects. The side-looking, circumferentially-scanning probe is inserted down the instrument channel of a standard bronchoscope and manually guided to the imaging location. Multiple images are collected with the probe spinning proximally at 100Hz. Due to friction, the distal end of the probe does not spin perfectly synchronous with the proximal end, resulting in non-uniform rotational distortion (NURD) of the images. First, we apply a correction algorithm to remove NURD. We then use a speckle variance algorithm to identify vasculature. The initial data show a vascaulture density in small human airways similar to what would be expected.

Paper Details

Date Published: 17 February 2012
PDF: 7 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82073P (17 February 2012); doi: 10.1117/12.906903
Show Author Affiliations
Michelle Cua, The BC Cancer Agency Research Ctr. (Canada)
Simon Fraser Univ. (Canada)
Anthony M. D. Lee, The BC Cancer Agency Research Ctr. (Canada)
Pierre M. Lane, The BC Cancer Agency Research Ctr. (Canada)
Annette McWilliams, The BC Cancer Agency Research Ctr. (Canada)
Tawimas Shaipanich, The BC Cancer Agency Research Ctr. (Canada)
Calum E. MacAulay, The BC Cancer Agency Research Ctr. (Canada)
Victor X. D. Yang, Ryerson Univ. (Canada)
Stephen Lam, The BC Cancer Agency Research Ctr. (Canada)


Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory M.D.; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg M.D.; Melissa J. Suter; Brian Jet-Fei Wong M.D.; Justus F. Ilgner M.D.; Stephen Lam; Bodo E. Knudsen M.D.; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney M.D.; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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