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Proceedings Paper

Optimizing magnetomotive contrast of SPIO-labeled platelets for thrombosis imaging in optical coherence tomography
Author(s): Amy L. Oldenburg; Dmitry Spivak; Gongting Wu; Frank Tsui; Thomas H. Fischer
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Paper Abstract

Rehydratable, lyophilized platelets loaded with superparamagnetic iron oxides (SPIOs) has the potential to provide magnetomotive imaging contrast to sites of vascular damage, including thrombosis complicating atherosclerosis and hemorrhage. Magnetomotive optical coherence tomography (MMOCT) contrasts SPIO-platelets based on their nanoscale, magnetically-induced motion. We report improvements in MMOCT imaging contrast and sensitivity by optimizing the magnetic properties and SPIO loading of the platelets. SPIO-platelets have been shown to specifically adhere to sites of vascular damage in porcine arteries ex vivo. This may lead to new methods for detecting internal bleeding and monitoring the formation of blood clots using infused SPIO-platelets.

Paper Details

Date Published: 1 February 2012
PDF: 6 pages
Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82131N (1 February 2012); doi: 10.1117/12.906837
Show Author Affiliations
Amy L. Oldenburg, The Univ. of North Carolina at Chapel Hill (United States)
Dmitry Spivak, The Univ. of North Carolina at Chapel Hill (United States)
Gongting Wu, The Univ. of North Carolina at Chapel Hill (United States)
Frank Tsui, The Univ. of North Carolina at Chapel Hill (United States)
Thomas H. Fischer, The Univ. of North Carolina at Chapel Hill (United States)


Published in SPIE Proceedings Vol. 8213:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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