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Proceedings Paper

Quantification of optical absorption coefficient from acoustic spectra in the optical diffusive regime using photoacoustic microscopy
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Paper Abstract

Photoacoustic (PA) tomography (PAT) can image optical absorption contrast with ultrasonic spatial resolution in the optical diffusive regime. Multi-wavelength PAT can noninvasively monitor hemoglobin oxygen saturation (sO2) with high sensitivity and fine spatial resolution. However, accurate quantification in PAT requires knowledge of the optical fluence distribution, acoustic wave attenuation, and detection system bandwidth. We propose a method to circumvent this requirement using acoustic spectra of PA signals acquired at two optical wavelengths. With the acoustic spectral method, the absorption coefficients of an oxygenated bovine blood phantom at 560 and 575 nm were quantified with errors of ><5%.

Paper Details

Date Published: 23 February 2012
PDF: 8 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82234C (23 February 2012); doi: 10.1117/12.906787
Show Author Affiliations
Zijian Guo, Washington Univ. in St. Louis (United States)
Christopher Favazza, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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