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Proceedings Paper

Magnetic resonance thermometry for monitoring photothermal effects of interstitial laser irradiation
Author(s): Jessica Goddard; Jessnie Jose; Daniel Figueroa; Kelvin Le; Hong Liu; Robert E. Nordquist; Tomas Hode; Wei R. Chen
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Paper Abstract

Selective photothermal interaction using dye-assisted non-invasive laser irradiation has limitations when treating deeper tumors or when the overlying skin is heavily pigmented. We developed an interstitial laser irradiation method to induce the desired photothermal effects. An 805-nm near-infrared laser with a cylindrical diffuser was used to treat rat mammary tumors by placing the active tip of the fiber inside the target tumors. Three different power settings (1.0 to 1.5 watts) were applied to treat animal tumors with an irradiation duration of 10 minutes. The temperature distributions of the treated tumors were measured by a 7.1-Tesla magnetic resonance imager using proton resonance frequency (PRF) method. Three-dimensional temperature profiles were reconstructed and assessed using PRF. This is the first time a 7.1-Tesla magnetic resonance imager has been used to monitor interstitial laser irradiation via PRF. This study provides a basic understanding of the photothermal interaction needed to control the thermal damage inside tumor using interstitial laser irradiation. It also shows that PRF can be used effectively in monitoring photothermal interaction. Our long-term goal is to develop a PRF-guided laser therapy for cancer treatment.

Paper Details

Date Published: 9 February 2012
PDF: 11 pages
Proc. SPIE 8224, Biophotonics and Immune Responses VII, 82240A (9 February 2012); doi: 10.1117/12.906555
Show Author Affiliations
Jessica Goddard, Univ. of Central Oklahoma (United States)
Jessnie Jose, Univ. of Central Oklahoma (United States)
Daniel Figueroa, Univ. of Central Oklahoma (United States)
Kelvin Le, Univ. of Central Oklahoma (United States)
Hong Liu, The Univ. of Oklahoma (United States)
Robert E. Nordquist, ImmunoPhotonics, Inc. (United States)
Tomas Hode, Immunophotonics, Inc. (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 8224:
Biophotonics and Immune Responses VII
Wei R. Chen, Editor(s)

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