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Proceedings Paper

Computer simulation of lipid bilayer detection using ion-sensitive field-effect transistors
Author(s): Shigeyasu Uno
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Paper Abstract

Computer simulation of lipid bilayer detection using ion-sensitive field-effect transistors (ISFETs) is presented. Based on a previous work addressing DNA sensing using ISFETs, lipid bilayers on ISFET sensor surface is modeled. The model consists of (a) sensor surface, (b) Stern layer, (c) thin electrolytic layer, (d) lipid bilayer, and (e) semi-infinitely-extended electrolyte domain. Poisson-Boltzmann equation is solved to determine electrostatics taking into account mobile ion charges in electrolyte and lipid charges. The simulation successfully reproduces experimental results of output signal change due to positively-charged lipid molecular concentration, as well as salt ion concentration.

Paper Details

Date Published: 2 February 2012
PDF: 6 pages
Proc. SPIE 8231, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII, 82310V (2 February 2012); doi: 10.1117/12.906521
Show Author Affiliations
Shigeyasu Uno, Ritsumeikan Univ. (Japan)


Published in SPIE Proceedings Vol. 8231:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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