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Proceedings Paper

Influence of hemoglobin on non-invasive optical bilirubin sensing
Author(s): Jingying Jiang; Qiliang Gong; Da Zou; Kexin Xu
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Paper Abstract

Since the abnormal metabolism of bilirubin could lead to diseases in the human body, especially the jaundice which is harmful to neonates. Traditional invasive measurements are difficult to be accepted by people because of pain and infection. Therefore, the real-time and non-invasive measurement of bilirubin is of great significance. However, the accuracy of currently transcutaneous bilirubinometry(TcB) is generally not high enough, and affected by many factors in the human skin, mostly by hemoglobin. In this talk, absorption spectra of hemoglobin and bilirubin have been collected and analyzed, then the Partial Least Squares (PLS) models have been built. By analyzing and comparing the Correlation and Root Mean Square Error of Prediction(RMSEP), the results show that the Correlation of bilirubin solution model is larger than that of the mixture solution added with hemoglobin, and its RMSEP value is smaller than that of mixture solution. Therefore, hemoglobin has influences on the non-invasive optical bilirubin sensing. In next step, it is necessary to investigate how to eliminate the influence.

Paper Details

Date Published: 9 February 2012
PDF: 7 pages
Proc. SPIE 8222, Dynamics and Fluctuations in Biomedical Photonics IX, 822218 (9 February 2012); doi: 10.1117/12.906509
Show Author Affiliations
Jingying Jiang, Tianjin Univ. (China)
Qiliang Gong, Tianjin Univ. (China)
Da Zou, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 8222:
Dynamics and Fluctuations in Biomedical Photonics IX
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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