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Proceedings Paper

Compact Stokes shift and fluorescence spectroscopic diagnostics LED ratiometer unit with no moving parts for cancer detection
Author(s): Laura A. Sordillo; Yang Pu; Yury Budansky; R. R. Alfano
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Paper Abstract

A compact Stokes shift and fluorescence spectroscopy (S3) LED device with no moving parts is presented. This device can be used diagnostically for the identification of the native biomolecules within cancerous tissue samples. This S3-LED ratiometer unit measures both the emission and absorption spectra of key native organic biomolecules within a tissue sample by using multiple wavelength LEDs (light emitting diodes) coupled to an optical fiber. Thus, an optical fingerprint of the sample can be obtained. This technique could be used to distinguish benign and malignant tissues, and to check for residual or recurrent carcinoma after treatment, thus reducing the necessity of second biopsies. The S3-LED ratiometer unit was tested in vitro on human breast malignant and normal paired tissue samples.

Paper Details

Date Published: 16 February 2012
PDF: 7 pages
Proc. SPIE 8220, Optical Biopsy X, 82200I (16 February 2012); doi: 10.1117/12.906487
Show Author Affiliations
Laura A. Sordillo, The City College of New York (United States)
Yang Pu, The City College of New York (United States)
Yury Budansky, The City College of New York (United States)
R. R. Alfano, The City College of New York (United States)

Published in SPIE Proceedings Vol. 8220:
Optical Biopsy X
Robert R. Alfano; Stavros G. Demos, Editor(s)

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