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Proceedings Paper

Pulsed vs. CW low level light therapy on osteoarticular signs and symptoms in limited scleroderma (CREST syndrome)
Author(s): Daniel Barolet
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Paper Abstract

Limited cutaneous systemic sclerosis (lcSSc) was formerly known as CREST syndrome in reference to the associated clinical features: Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasias. The transforming growth factor beta (TGF-β) has been identified has a major player in the pathogenic process, while low level light therapy (LLLT) has been shown to modulate this cytokine superfamily. This case study was conducted to assess the efficacy of 940nm using microsecond domain pulsing and continuous wave mode (CW) on osteoarticular signs and symptoms associated with lcSSc. The patient was treated two to three times a week for 13 weeks, using a sequential pulsing mode on one elbow, and a CW mode on the other. Efficacy assessments included inflammation, symptoms, pain, and health scales, patient satisfaction, clinical global impression, and adverse effects monitoring. Significant functional and morphologic improvements were observed after LLLT, with best results seen with the pulsing mode. No significant adverse effects were noted. Two mechanisms of action may be at play. The 940nm wavelength provides inside-out heating possibly vasodilating capillaries which in turn increases catabolic processes leading to a reduction of in situ calcinosis. LLLT may also improve symptoms by triggering a cascade of cellular reactions, including the modulation of inflammatory mediators.

Paper Details

Date Published: 10 March 2012
PDF: 8 pages
Proc. SPIE 8211, Mechanisms for Low-Light Therapy VII, 82110F (10 March 2012); doi: 10.1117/12.906476
Show Author Affiliations
Daniel Barolet, RoseLab Skin Optics Research Lab. (Canada)
McGill Univ. (Canada)


Published in SPIE Proceedings Vol. 8211:
Mechanisms for Low-Light Therapy VII
Michael R. Hamblin; Juanita Anders; James D. Carroll, Editor(s)

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