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Proceedings Paper

Integrated optical sensor array for biochemical multiparameter analysis
Author(s): Daniel Pergande; Peter Lützow; Sophie Huscher; Dominik Gausa; Helmut Heidrich
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Paper Abstract

In this paper we demonstrate the ability to analyze a multiple of miniaturized bus-integrated sensor elements at high sensitivity from the superimposed complex overall spectrum by individual frequency modulation of optical microring resonators (MRR) fed by a single bus waveguide. The diverse sensor elements can be coated with biochemically selective adlayers (e.g., antibody molecules) to specifically promote the accumulation of target molecules on the MRR surface. Adhesion of target molecules results in an increase of the MRR resonance frequencies which can be measured at high sensitivity with a picometer accuracy. Readout of each MRR from the complex overall spectrum is performed by using phase sensitive lock-in detection to filter out the individual and selective response to external stimuli. We fabricated test arrays with 12 MRR elements based on silicon nitride material, each element integrated with a heater electrode for thermo-optical modulation of the MRR. A clear readout of the individual MRR by using a tuneable laser source is accomplished in a simple and reliable manner via lock-in detection despite strong overlap of the individual resonances. With our first results, we point out the large potential for multiplexed label-free detection of diverse biomolecular compounds.

Paper Details

Date Published: 31 January 2012
PDF: 7 pages
Proc. SPIE 8212, Frontiers in Biological Detection: From Nanosensors to Systems IV, 82120L (31 January 2012); doi: 10.1117/12.906375
Show Author Affiliations
Daniel Pergande, Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute (Germany)
Peter Lützow, Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute (Germany)
Sophie Huscher, Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute (Germany)
Dominik Gausa, Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute (Germany)
Helmut Heidrich, Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute (Germany)


Published in SPIE Proceedings Vol. 8212:
Frontiers in Biological Detection: From Nanosensors to Systems IV
Benjamin L. Miller; Philippe M. Fauchet, Editor(s)

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