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Proceedings Paper

Measuring tissue blood flow using ultrasound modulated diffused light
Author(s): A. Ron; N. Racheli; I. Breskin; Y. Metzger; Z. Silman; M. Kamar; A. Nini; R. Shechter; M. Balberg
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Paper Abstract

We demonstrate the ability of a novel device employing ultrasound modulation of near infrared light (referred as "Ultrasound tagged light" or UTL) to perform non-invasive monitoring of blood flow in the microvascular level in tissue. Monitoring microcirculatory blood flow is critical in clinical situations affecting flow to different organs, such as the brain or the limbs. . However, currently there are no non-invasive devices that measure microcirculatory blood flow in deep tissue continuously. Our prototype device (Ornim Medical, Israel) was used to monitor tissue blood flow on anesthetized swine during controlled manipulations of increased and decreased blood flow. Measurements were done on the calf muscle and forehead of the animal and compared with Laser Doppler (LD). ROC analysis of the sensitivity and specificity for detecting an increase in blood flow on the calf muscle, demonstrated AUC = 0.951 for 23 systemic manipulations of cardiac output by Epinephrine injection, which is comparable to AUC = 0.943 using laser Doppler. Some examples of cerebral blood flow monitoring are presented, along with their individual ROC curves. UTL flowmetry is shown to be effective in detecting changes in cerebral and muscle blood flow in swine, and has merit in clinical applications.

Paper Details

Date Published: 23 February 2012
PDF: 7 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82232J (23 February 2012); doi: 10.1117/12.906349
Show Author Affiliations
A. Ron, Ornim Medical Ltd. (Israel)
N. Racheli, Ornim Medical Ltd. (Israel)
I. Breskin, Ornim Medical Ltd. (Israel)
Y. Metzger, Ornim Medical Ltd. (Israel)
Z. Silman, Ornim Medical Ltd. (Israel)
M. Kamar, Ornim Medical Ltd. (Israel)
A. Nini, Ornim Medical Ltd. (Israel)
R. Shechter, Ornim Medical Ltd. (Israel)
M. Balberg, Ornim Medical Ltd. (Israel)

Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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