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Proceedings Paper

Monitoring the morphochemistry of laryngeal carcinoma by multimodal imaging
Author(s): Tobias Meyer; Christoph Krafft; Orlando Guntinas-Lichius; Ferdinand von Eggeling; Günther Ernst; Benjamin Dietzek; Jürgen Popp
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Paper Abstract

Multimodal nonlinear imaging constitutes a contemporary approach to investigate the morphochemistry of complex samples noninvasively and without administration of external labels. Here we discuss our recent success in jointly using various nonlinear microspectroscopic approaches such as coherent anti-Stokes Raman scattering (CARS), two-photon fluorescence (TPF) and second-harmonic generation (SHG) to study the chemical composition of surgically removed tissue sections from laryngeal carcinoma. In particular it will be shown how multimodal nonlinear imaging can be employed to study the structural and chemical development of disease formation as well as to monitor the clinically important aspect of tumor boundary detection.

Paper Details

Date Published: 31 January 2012
PDF: 6 pages
Proc. SPIE 8220, Optical Biopsy X, 82200R (31 January 2012); doi: 10.1117/12.906180
Show Author Affiliations
Tobias Meyer, Institute of Photonic Technology (Germany)
Christoph Krafft, Institute of Photonic Technology (Germany)
Orlando Guntinas-Lichius, Univ. Hospital Jena (Germany)
Ferdinand von Eggeling, Univ. Hospital Jena (Germany)
Günther Ernst, Univ. Hospital Jena (Germany)
Benjamin Dietzek, Institute of Photonic Technology (Germany)
Friedrich-Schiller-Univ. Jena (Germany)
Jürgen Popp, Institute of Photonic Technology (Germany)
Friedrich-Schiller-Univ. Jena (Germany)

Published in SPIE Proceedings Vol. 8220:
Optical Biopsy X
Robert R. Alfano; Stavros G. Demos, Editor(s)

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