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Proceedings Paper

Time-resolved single molecule microscopy coupled with atomic force microscopy
Author(s): M. König; F. Koberling; O. Schulz; R. Ros; S. Fore; M. Sackrow; S. Trautmann; R. Erdmann
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Paper Abstract

Time-resolved confocal microscopy is well established to image spectral and spatial properties of samples in biology and material science. Atomic Force Microscopy (AFM) in addition enables to investigate properties which are not optically addressable or are hidden by the diffraction limited optical resolution. We present a straight forward combination of single molecule sensitive time-resolved confocal microscopy with different commercially available AFMs. Besides an extra of information about for example a cell surface, the AFM tip can also be used to manipulate the sample on a nanometer scale down to the single molecule level.

Paper Details

Date Published: 3 February 2012
PDF: 7 pages
Proc. SPIE 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, 822719 (3 February 2012); doi: 10.1117/12.906177
Show Author Affiliations
M. König, PicoQuant GmbH (Germany)
F. Koberling, PicoQuant GmbH (Germany)
O. Schulz, Arizona State Univ. (United States)
R. Ros, Arizona State Univ. (United States)
S. Fore, PicoQuant Photonics North America, Inc. (United States)
M. Sackrow, PicoQuant GmbH (Germany)
S. Trautmann, PicoQuant GmbH (Germany)
R. Erdmann, PicoQuant GmbH (Germany)


Published in SPIE Proceedings Vol. 8227:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX
Jose-Angel Conchello; Carol J. Cogswell; Tony Wilson; Thomas G. Brown, Editor(s)

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