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Proceedings Paper

Fighting cancer with magnetic nanoparticles and immunotherapy
Author(s): L. Gutiérrez; R. Mejías; D. F. Barber; S. Veintemillas-Verdaguer; C. J. Serna; F. J. Lázaro; M. P. Morales
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Paper Abstract

IFN-γ-adsorbed DMSA-coated magnetite nanoparticles can be used as an efficient in vivo drug delivery system for tumor immunotherapy. Magnetic nanoparticles, with adsorbed interferon-γ, were targeted to the tumor site by application of an external magnetic field. A relevant therapeutic dosage of interferon in the tumor was detected and led to a notable reduction in tumor size. In general, only 10% of the total injected nanoparticles after multiple exposures were found in tissues by AC susceptibility measurements of the corresponding resected tissues. Magnetic nanoparticle biodistribution is affected by the application of an external magnetic field.

Paper Details

Date Published: 2 February 2012
PDF: 8 pages
Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320X (2 February 2012); doi: 10.1117/12.905890
Show Author Affiliations
L. Gutiérrez, Instituto de Ciencia de Materiales de Madrid (Spain)
R. Mejías, Consejo Superior de Investigaciones Científicas (Spain)
D. F. Barber, Consejo Superior de Investigaciones Científicas (Spain)
S. Veintemillas-Verdaguer, Instituto de Ciencia de Materiales de Madrid (Spain)
C. J. Serna, Instituto de Ciencia de Materiales de Madrid (Spain)
F. J. Lázaro, Univ. de Zaragoza (Spain)
M. P. Morales, Instituto de Ciencia de Materiales de Madrid (Spain)


Published in SPIE Proceedings Vol. 8232:
Colloidal Nanocrystals for Biomedical Applications VII
Wolfgang J. Parak; Kenji Yamamoto; Marek Osinski, Editor(s)

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