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Proceedings Paper

In vivo studies of low level laser (light) therapy for traumatic brain injury
Author(s): Weijun Xuan; Qiuhe Wu; Ying-Ying Huang; Takahiro Ando; Liyi Huang; Michael R. Hamblin
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Paper Abstract

Low-level laser (or light) therapy (LLLT) is attracting growing interest to treat both stroke and traumatic brain injury (TBI). The fact that near-infrared light can penetrate into the brain allows non-invasive treatment to be carried out with a low likelihood of treatment-related adverse events. It is proposed that red and NIR light is absorbed by chromophores in the mitochondria of cells leading to changes in gene transcription and upregulation of proteins involved in cell survival, antioxidant production, collagen synthesis, reduction of chronic inflammation and cell migration and proliferation. We developed a mouse model of controlled cortical impact (CCI) TBI and examined the effect of 0, 1, 3, and 14 daily 810-nm CW laser treatments in the CCI model as measured by neurological severity score and wire grip and motion test. 1 laser Tx gave a significant improvement while 3 laser Tx was even better. Surprisingly 14 laser Tx was no better than no treatment. Histological studies at necropsy suggested that the neurodegeneration was reduced at 14 days and that the cortical lesion was repaired by BrdU+ve neural progenitor (stem) cells at 28 days. Transcranial laser therapy is a promising treatment for acute (and chronic TBI) and the lack of side-effects and paucity of alternative treatments encourages early clinical trials.

Paper Details

Date Published: 9 March 2012
PDF: 10 pages
Proc. SPIE 8211, Mechanisms for Low-Light Therapy VII, 82110A (9 March 2012); doi: 10.1117/12.905782
Show Author Affiliations
Weijun Xuan, Wellman Ctr. of Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Traditional Chinese Medical Univ. of Guangxi (China)
Qiuhe Wu, Wellman Ctr. of Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Jinan Ctr. Hospital (China)
Ying-Ying Huang, Wellman Ctr. of Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Guangxi Medical Univ. (China)
Takahiro Ando, Wellman Ctr. of Photomedicine, Massachusetts General Hospital (United States)
Keio Univ. (Japan)
Liyi Huang, Wellman Ctr. of Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Guangxi Medical Univ. (China)
Michael R. Hamblin, Wellman Ctr. of Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Harvard-MIT Division of Health Sciences and Technology (United States)


Published in SPIE Proceedings Vol. 8211:
Mechanisms for Low-Light Therapy VII
Michael R. Hamblin; Juanita Anders; James D. Carroll, Editor(s)

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