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Proceedings Paper

Sensitive detection of nitric oxide using a 5.26 μm external cavity quantum cascade laser based QEPAS sensor
Author(s): Frank K. Tittel; Lei Dong; Rafal Lewicki; George Lee; Adjani Peralta; Vincenzo Spagnolo
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Paper Abstract

The development and performance of a continuous wave (CW), thermoelectrically cooled (TEC) external cavity quantum cascade laser (EC-QCL) based sensor for quantitative measurements of nitric oxide (NO) concentrations in exhaled breath will be reported. Human breath contains ~ 400 different chemical species, usually at ultra low concentration levels, which can serve as biomarkers for the identification and monitoring of human diseases or wellness states. By monitoring exhaled NO concentration levels, a fast non-invasive diagnostic method for treatment of patients with asthma and chronic obstructive pulmonary disease (COPD) is feasible. The NO concentration measurements are performed with a 2f wavelength modulation based quartz enhanced photoacoustic spectroscopy (QEPAS) technique, which is very suitable for real time breath measurements, due to the fast gas exchange inside a compact QEPAS gas cell (<5 mm3 typical volume). In order to target the optimal interference free NO R (6.5) absorption doublet at 1900.08 cm-1(λ~5.263 μm) a Daylight Solutions Inc. widely tunable, mode-hop free 100 mW EC-QCL was used. The sensor reference channel includes a 10 cm long reference cell, filled with a 0.5% NO in N2 at 150 Torr, which is used for line-locking purpose. A minimum detection limit (1σ) for the EC-QCL based line locked NO sensor is ~5 ppbv with a 1 sec update time by a custom built control QCL compatible electronics unit.

Paper Details

Date Published: 20 January 2012
PDF: 8 pages
Proc. SPIE 8268, Quantum Sensing and Nanophotonic Devices IX, 82680F (20 January 2012); doi: 10.1117/12.905621
Show Author Affiliations
Frank K. Tittel, Rice Univ. (United States)
Lei Dong, Rice Univ. (United States)
Rafal Lewicki, Rice Univ. (United States)
George Lee, Rice Univ. (United States)
Adjani Peralta, Rice Univ. (United States)
Vincenzo Spagnolo, Politecnico di Bari (Italy)

Published in SPIE Proceedings Vol. 8268:
Quantum Sensing and Nanophotonic Devices IX
Manijeh Razeghi; Eric Tournie; Gail J. Brown, Editor(s)

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