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Proceedings Paper

Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for long-allele carriers during perceptual processing of emotional tasks
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Paper Abstract

A negative blood oxygen level - dependent (BOLD) has been associated with a high concentration of GABA using Magnetic Resonance Spectroscopy and fMRI. Subjects with long-allele carriers have seen with high concentration of serotonin in Rostral Subgenual portion of the anterior cingulate cortex (rACC). In this paper, we investigate the effect of serotonin concentration on hemodynamic responses. Our results show a negative BOLD signal in rACC in the subjects with long-allele carriers. In contrast, the subjects with short-allele carriers showed positive BOLD signals in rACC. These results suggest that the serotonin transporter gene impacts the neuronal activity and eventually the BOLD signal similar to GABA.

Paper Details

Date Published: 13 April 2012
PDF: 7 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83170A (13 April 2012); doi: 10.1117/12.905188
Show Author Affiliations
Shamil M. Hadi, Oakland Univ. (United States)
Mohamad R. Siadat, Oakland Univ. (United States)
Abbas Babajani-Feremi, Washington University in St. Louis School of Medicine (United States)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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