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Proceedings Paper

Bimetallic chips for SMX sensing in a surface plasmon resonance instrument
Author(s): Yong Chen; Yonghua Lu; Douguo Zhang; Pei Wang; Hai Ming
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Paper Abstract

We replace a commonly used Au film with an Au/Ag bimetallic film working as the sensing chip in the commercial surface plasmon resonance (SPR) instrument, Biacore 3000. The bimetallic chip gives out sharper SPR dip than that by the chip made of an Au film which can improve the sensitivity and accuracy. The applicability and stability of the bimetallic chip on the Biacore 3000 are tested by real-time monitoring of biological coupling processes between Sulfamethoxazole (SMX) and anti-SMX. The limit of detection of SMX is 1.8ng/ml.

Paper Details

Date Published: 5 December 2011
PDF: 8 pages
Proc. SPIE 8198, 2011 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Integration, 81980J (5 December 2011); doi: 10.1117/12.904715
Show Author Affiliations
Yong Chen, Univ. of Science and Technology of China (China)
Yonghua Lu, Univ. of Science and Technology of China (China)
Douguo Zhang, Univ. of Science and Technology of China (China)
Pei Wang, Univ. of Science and Technology of China (China)
Hai Ming, Univ. of Science and Technology of China (China)


Published in SPIE Proceedings Vol. 8198:
2011 International Conference on Optical Instruments and Technology: Optoelectronic Devices and Integration
Xuping Zhang; P. K. Alex Wai; Hai Ming, Editor(s)

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