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Proceedings Paper

A highly sensitive biological detection substrate based on TiO2 nanowires supporting gold nanoparticles
Author(s): Yuan Zeng; Hai-jun Tan; Xiu-Lan Cheng; Rui Chen; Ying Wang
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Paper Abstract

Surface enhanced Raman scattering (SERS) has attracted widespread concern in the field of bioassay because it can enhance normally weak Raman signal by several orders of magnitude and facilitate the highly sensitive detection of molecules. Conventional SERS substrates are prepared by placing metal nanoparticles on a planar surface. Here we show a unique SERS substrate stacked by disordered TiO2 nanowires (TiO2-NWs) supportig gold nanocrystals. The structure can be easily fabricated by chemical synthesis at low cost. The COMSOL model simulation shows the designed SERS substrate is capable of output high Local Field Enhancement (LFE) in the Near Infrared region (NIR) that is the optimal wavelength in bio-detection because of both the unique coupling enhancement effect amony nearby Au nanocrystals on TiO2-NWs and the Suface Plasmon Resonance (SPR) effect of TiO2 -NWs. The as-prepared transparent and freestanding SERS substrate is capable of detecting extremely low concentration R6G molecular, showing much higher Raman signal because of the extremely large surface area and the uniqueTiO2-NWs self-assemblied by Au nanocrystals. These results provide a new approach to ultrasensitive bioassay device.

Paper Details

Date Published: 29 November 2011
PDF: 7 pages
Proc. SPIE 8311, Optical Sensors and Biophotonics III, 83110H (29 November 2011); doi: 10.1117/12.904317
Show Author Affiliations
Yuan Zeng, Shanghai Jiao Tong Univ. (China)
Hai-jun Tan, Shanghai Jiao Tong Univ. (China)
Xiu-Lan Cheng, Shanghai Jiao Tong Univ. (China)
Rui Chen, Shanghai Jiao Tong Univ. (China)
Ying Wang, Shanghai Jiao Tong Univ. (China)

Published in SPIE Proceedings Vol. 8311:
Optical Sensors and Biophotonics III
Jürgen Popp, Editor(s)

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