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Proceedings Paper

Cancer therapy utilizing molecular layer deposition (MLD) and self-organized lightwave network (SOLNET): proposal and theoretical prediction
Author(s): Tetsuzo Yoshimura; Chie Yoshino; Koyo Sasaki; Taishi Sato; Masatoshi Seki
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Paper Abstract

Cancer therapy utilizing Molecular Layer Deposition (MLD) and Self-Organized Lightwave Network (SOLNET) is proposed. MLD is a growth method, in which different kinds of molecules are sequentially provided to a substrate to synthesize organic tailored materials with designated molecular arrangements. In cancer therapy, the liquid-phase MLD (LP-MLD) is used with regarding the human body as the MLD chamber and the cancer cells as the substrates. The first proposal is the selective delivery of multi-functional materials with imaging, sensitizing, paramagnetic, lightabsorbing agents etc. to cancer cells by LP-MLD. The second proposal is in-situ synthesis of drugs, especially large and toxic ones, at cancer cells by LP-MLD to deliver the drugs deep inside the cancer without attacking normal cells. The third proposal is the SOLNET-assisted laser surgery. After luminescent molecules are adsorbed in cancer cells by LPMLD, a write beam is introduced from an optical fiber into the area containing cancer cells through photo-induced refractive index increase materials to construct self-aligned optical waveguides of SOLNET, which selectively guides surgery beams to cancer cells. Theoretical predictions and preliminary experimental results are presented.

Paper Details

Date Published: 2 February 2012
PDF: 8 pages
Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 823305 (2 February 2012); doi: 10.1117/12.902804
Show Author Affiliations
Tetsuzo Yoshimura, Tokyo Univ. of Technology (Japan)
Chie Yoshino, Tokyo Univ. of Technology (Japan)
Koyo Sasaki, Tokyo Univ. of Technology (Japan)
Taishi Sato, Tokyo Univ. of Technology (Japan)
Masatoshi Seki, Tokyo Univ. of Technology (Japan)


Published in SPIE Proceedings Vol. 8233:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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