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Proceedings Paper

Fiber optic nanoprobes for biological sensing
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Paper Abstract

Optical sensors have a large impact in the fields of life science research, drug discovery and medical diagnostics. The recent advances in nanotechnology and photonics have led to a new generation of nanotools, capable of probing even the single cell: it has already been demonstrated that nanobiosensors can detect biochemical targets and proteins inside living single cells. Here we provide a brief overview of the field of nanoprobes consisting of tapered, metal-coated optical fibers having nanosize tips, such as those which were originally developed for use in near-field optical microscopy. Moreover we present some preliminary results concerning the characterization of the experimental sensing system which exploits such nanoprobes for intracellular biomedical diagnostics. The feasibility of using the Fluorescence Lifetime Imaging Microscopy (FLIM) technique as a dynamic diagnostics tool with these nanoprobes has been demonstrated.

Paper Details

Date Published: 3 November 2011
PDF: 8 pages
Proc. SPIE 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World, 80118X (3 November 2011); doi: 10.1117/12.902801
Show Author Affiliations
Andrea Barucci, Isituto di Fisica Applicata Nello Carrara, CNR (Italy)
Simone Berneschi, Isituto di Fisica Applicata Nello Carrara, CNR (Italy)
Ctr. Studi e Ricerche e Museo Storico della Fisica Enrico Fermi (Italy)
Franco Cosi, Isituto di Fisica Applicata Nello Carrara, CNR (Italy)
Gualtiero Nunzi Conti, Isituto di Fisica Applicata Nello Carrara, CNR (Italy)
Stefano Pelli, Isituto di Fisica Applicata Nello Carrara, CNR (Italy)
Franco Quercioli, Istituto Nazionale di Ottica, CNR (Italy)
Silvia Soria, Isituto di Fisica Applicata Nello Carrara, CNR (Italy)
Giancarlo C. Righini, Isituto di Fisica Applicata Nello Carrara, CNR (Italy)


Published in SPIE Proceedings Vol. 8011:
22nd Congress of the International Commission for Optics: Light for the Development of the World

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