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Proceedings Paper

Determination of stereoisomer in sugars by THz-TDS
Author(s): S. Yamauchi; Y. Imai; H. Yokota; M. Tonouchi
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Paper Abstract

Transmission-type terahertz time-domain spectroscopy (THz-TDS) using dipole-antennas on LT-GaAs layers as THzemitter and detector with fs-fiber laser as the excitation light source was applied to determine the stereoisomer of sugars in carefully controlled environment with low humidity below 5% at 20°C. Commercially available α-D-lactose including about 4% anomer and β-D-lactose including below 30% anomer were used as stereoisomer samples. The absorption spectra of compounds by the α-D- and β-D-lactose powders with various ratios were successively deconvoluted to four spectra by Lorentzian and dependent on the composition ratio. Integrated absorptions due to α-D-lactose and β-D-lactose determined the decreasing rate (rα) and the increasing rate (rβ) for the composition ratio of the β-D-lactose powder, because the intensities were linearly dependent on the composition ratio. The net-composition ratio of α-lactose and β-lactose in the compounds was precisely evaluated by the ratio of the integrated intensities and the value of rβ / rα, for example, the anomer-contents in commercially available α-D-lactose and β-D-lactose powders were disclosed as 3.9% and 29.1%, respectively. The demonstrated results indicate that THz-TDS is so useful not only for precise qualitativeanalysis but also for precise quantitative-analysis of stereoisomer in sugars with partially different molecular structure such as lactose.

Paper Details

Date Published: 2 November 2011
PDF: 7 pages
Proc. SPIE 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World, 80118L (2 November 2011); doi: 10.1117/12.902044
Show Author Affiliations
S. Yamauchi, Ibaraki Univ. (Japan)
Y. Imai, Ibaraki Univ. (Japan)
H. Yokota, Ibaraki Univ. (Japan)
M. Tonouchi, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 8011:
22nd Congress of the International Commission for Optics: Light for the Development of the World
Ramón Rodríguez-Vera; Ramón Rodríguez-Vera; Ramón Rodríguez-Vera; Rufino Díaz-Uribe; Rufino Díaz-Uribe; Rufino Díaz-Uribe, Editor(s)

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