Share Email Print
cover

Proceedings Paper

Terahertz spectroscopic study of benzodiazepine sedative hypnotics
Author(s): Fusheng Deng; Jingling Shen; Xianfeng Wang
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Terahertz time domain spectroscopy (THz-TDS) is used to the pure active ingredient of three benzodiazepine sedative hypnotics with similar molecular structure. The absorption spectra of them are studied in the range of 0.2~2.6THz. Based on the experiment, the theoretical simulation results of diazepam, nitrazepam and clonazepam are got by the Gaussian03 package of DFT/B3LYP/6-31G* method in single-molecule models. The experimental results show that even if the molecular structure and medicine property of them are similar, the accurate identification of them can still be done with their characteristic absorption spectra. Theoretical simulation results are well consistent with the experimental results. It demonstrates that absorption peaks of them in THz range mainly come from intra-molecular forces and are less affected by the intermolecular interaction and crystal effects.ô

Paper Details

Date Published: 12 August 2011
PDF: 7 pages
Proc. SPIE 8195, International Symposium on Photoelectronic Detection and Imaging 2011: Terahertz Wave Technologies and Applications, 819517 (12 August 2011); doi: 10.1117/12.900786
Show Author Affiliations
Fusheng Deng, Capital Normal Univ. (China)
Shanxi Datong Univ. (China)
Jingling Shen, Capital Normal Univ. (China)
Xianfeng Wang, Shanxi Datong Univ. (China)


Published in SPIE Proceedings Vol. 8195:
International Symposium on Photoelectronic Detection and Imaging 2011: Terahertz Wave Technologies and Applications
X.-C. Zhang; Jianquan Yao; Cunlin Zhang; Zhenzhan Wang, Editor(s)

© SPIE. Terms of Use
Back to Top