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Proceedings Paper

The microfluidic bioagent autonomous networked detector (M-BAND): an update. Fully integrated, automated, and networked field identification of airborne pathogens
Author(s): M. Sanchez; L. Probst; E. Blazevic; B. Nakao; M. A. Northrup
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Paper Abstract

We describe a fully automated and autonomous air-borne biothreat detection system for biosurveillance applications. The system, including the nucleic-acid-based detection assay, was designed, built and shipped by Microfluidic Systems Inc (MFSI), a new subsidiary of PositiveID Corporation (PSID). Our findings demonstrate that the system and assay unequivocally identify pathogenic strains of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, and Burkholderia pseudomallei. In order to assess the assay's ability to detect unknown samples, our team also challenged it against a series of blind samples provided by the Department of Homeland Security (DHS). These samples included natural occurring isolated strains, near-neighbor isolates, and environmental samples. Our results indicate that the multiplex assay was specific and produced no false positives when challenged with in house gDNA collections and DHS provided panels. Here we present another analytical tool for the rapid identification of nine Centers for Disease Control and Prevention category A and B biothreat organisms.

Paper Details

Date Published: 13 October 2011
PDF: 7 pages
Proc. SPIE 8189, Optics and Photonics for Counterterrorism and Crime Fighting VII; Optical Materials in Defence Systems Technology VIII; and Quantum-Physics-based Information Security, 818907 (13 October 2011); doi: 10.1117/12.898650
Show Author Affiliations
M. Sanchez, Microfluidic Systems, Inc. (United States)
L. Probst, Microfluidic Systems, Inc. (United States)
E. Blazevic, Microfluidic Systems, Inc. (United States)
B. Nakao, Microfluidic Systems, Inc. (United States)
M. A. Northrup, Microfluidic Systems, Inc. (United States)


Published in SPIE Proceedings Vol. 8189:
Optics and Photonics for Counterterrorism and Crime Fighting VII; Optical Materials in Defence Systems Technology VIII; and Quantum-Physics-based Information Security
Roberto Zamboni; Mark T. Gruneisen; Colin Lewis; Miloslav Dusek; Douglas Burgess; François Kajzar; Attila A. Szep; John G. Rarity, Editor(s)

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