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Proceedings Paper

Optical investigation of medicine solutions in micro-droplets form at interaction with laser radiation
Author(s): V. Nastasa; M. Boni; I. R. Andrei; L. Amaral; A. Staicu; M. L. Pascu
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Paper Abstract

One of the alternatives to the existing medicines and treatment procedures in fighting multi drug resistance (MDR) is strengthening the effects of medicines by modifying their molecular structures through exposure to laser radiation. A method associated with this, is the generation of micro-droplets which contain medicines solutions; the droplets are utilized/produced as vectors to transport the medicines to targets. In our studies we try to combine these two methods in order to obtain a new technique to deliver the efficient medicines to targets that can be applied for a relative large number of chemicals. For this purpose we have developed an experimental set-up containing a liquid droplets generator, a tunable laser source used to irradiate droplets, a subunit to measure the laser induced fluorescence (LIF) signals and a real time recording system for droplet image analysis. Measurements on different probes, like ultrapure water, commercial grade medicines, newly developed medicines and laser dyes were performed.. All these measurements were performed on waterbased solutions. We present in this paper the laser induced fluorescence measurements results on medicine solutions (in bulk or in a micro-droplet form) that exhibit important modifications after the exposure at laser radiation. It was evidenced that the exposures to laser beams/coherent optical radiation of some medicines solutions in ultrapure water may produce molecular modifications in solutions. These slight modifications of the molecules made them more efficient against bacteria strains.

Paper Details

Date Published: 16 September 2011
PDF: 7 pages
Proc. SPIE 8098, Physical Chemistry of Interfaces and Nanomaterials X, 809815 (16 September 2011); doi: 10.1117/12.898487
Show Author Affiliations
V. Nastasa, National Institute for Lasers, Plasma and Radiation Physics (Romania)
M. Boni, National Institute for Lasers, Plasma and Radiation Physics (Romania)
I. R. Andrei, National Institute for Lasers, Plasma and Radiation Physics (Romania)
L. Amaral, Univ. Nova de Lisboa (Portugal)
A. Staicu, National Institute for Lasers, Plasma and Radiation Physics (Romania)
M. L. Pascu, National Institute for Lasers, Plasma and Radiation Physics (Romania)


Published in SPIE Proceedings Vol. 8098:
Physical Chemistry of Interfaces and Nanomaterials X
Carlos Silva, Editor(s)

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