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Proceedings Paper

Quantification of tissue oxygenation levels using diffuse reflectance spectroscopy
Author(s): Suresh Anand B. S.; Sujatha N.
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Paper Abstract

Tumor growth is characterized by increased metabolic activity. The light absorption profile of hemoglobin in dysplastic tissue is different from a normal tissue. Neovascularization is a hallmark of many diseases and can serve as a predictive biomarker for the detection of cancers. Spectroscopic techniques can provide information about the metabolic and morphological changes related to the progression of neoplasia. Diffuse reflectance spectroscopy (DRS) measures the absorption and scattering properties of a biological tissue and this method can provide clinically useful information for the early diagnosis of epithelial precancers. We used tissue simulating phantoms with absorbing and scattering molecules for the determination of total hemoglobin concentration, hemoglobin oxygen saturation and intensity difference between the deoxy and oxy hemoglobin bands. The results show promising approach for the differentiating normal and malignant states of a tissue.

Paper Details

Date Published: 23 August 2011
PDF: 6 pages
Proc. SPIE 8173, Photonics 2010: Tenth International Conference on Fiber Optics and Photonics, 817308 (23 August 2011); doi: 10.1117/12.897811
Show Author Affiliations
Suresh Anand B. S., Indian Institute of Technology Madras (India)
Sujatha N., Indian Institute of Technology Madras (India)

Published in SPIE Proceedings Vol. 8173:
Photonics 2010: Tenth International Conference on Fiber Optics and Photonics
Sunil K. Khijwania; Banshi D. Gupta; Bishnu P. Pal; Anurag Sharma, Editor(s)

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