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Proceedings Paper

Dose reduction in molecular breast imaging
Author(s): Douglas J. Wagenaar; Samir Chowdhury; James W. Hugg; Rex A. Moats; Bradley E. Patt
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Paper Abstract

Molecular Breast Imaging (MBI) is the imaging of radiolabeled drugs, cells, or nanoparticles for breast cancer detection, diagnosis, and treatment. Screening of broad populations of women for breast cancer with mammography has been augmented by the emergence of breast MRI in screening of women at high risk for breast cancer. Screening MBI may benefit the sub-population of women with dense breast tissue that obscures small tumors in mammography. Dedicated breast imaging equipment is necessary to enable detection of early-stage tumors less than 1 cm in size. Recent progress in the development of these instruments is reviewed. Pixellated CZT for single photon MBI imaging of 99mTc-sestamibi gives high detection sensitivity for early-stage tumors. The use of registered collimators in a near-field geometry gives significantly higher detection efficiency - a factor of 3.6-, which translates into an equivalent dose reduction factor given the same acquisition time. The radiation dose in the current MBI procedure has been reduced to the level of a four-view digital mammography study. In addition to screening of selected sub-populations, reduced MBI dose allows for dual-isotope, treatment planning, and repeated therapy assessment studies in the era of molecular medicine guided by quantitative molecular imaging.

Paper Details

Date Published: 15 September 2011
PDF: 10 pages
Proc. SPIE 8143, Medical Applications of Radiation Detectors, 814307 (15 September 2011); doi: 10.1117/12.897496
Show Author Affiliations
Douglas J. Wagenaar, Children's Hospital of Los Angeles (United States)
Univ. of Southern California (United States)
Samir Chowdhury, Gamma Medica, Inc. (United States)
James W. Hugg, Gamma Medica, Inc. (United States)
Rex A. Moats, Children's Hospital of Los Angeles (United States)
The Univ. of Southern California (United States)
Bradley E. Patt, Gamma Medica, Inc. (United States)


Published in SPIE Proceedings Vol. 8143:
Medical Applications of Radiation Detectors
H. Bradford Barber; Hans Roehrig; Douglas J. Wagenaar, Editor(s)

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