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Proceedings Paper

Two-photon absorbing chromophores for photodynamic therapy: molecular engineering and in vivo applications
Author(s): Cyrille Monnereau; Thibault Gallavardin; Chloé Armagnat; Pierre-Henri Lanoé; Olivier Maury; Sophie Marotte; Yann Leverrier; Patrice L. Baldeck; Chantal Andraud
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Paper Abstract

Recent examples of our works in the field of molecular engineering of chromophores for two-photon photodynamic therapy (PDT), and their vectorization into biological medium are presented and discussed. In a first section of this article, we show that a commercial amphiphilic diblock copolymer can be used as a micellar container for efficient delivery of s standard two-photon PDT sensitizer into cells. In a second section, we show how a simple molecular engineering strategy can be used to improve the performances of two-photon PDT sensitizer in the biological transparency-window.

Paper Details

Date Published: 15 September 2011
PDF: 9 pages
Proc. SPIE 8103, Nanobiosystems: Processing, Characterization, and Applications IV, 81030N (15 September 2011); doi: 10.1117/12.895984
Show Author Affiliations
Cyrille Monnereau, Ecole Normale Supérieure de Lyon, CNRS, Univ. de Lyon (France)
Thibault Gallavardin, Ecole Normale Supérieure de Lyon, CNRS, Univ. de Lyon (France)
Chloé Armagnat, Ecole Normale Supérieure de Lyon, CNRS, Univ. de Lyon (France)
Pierre-Henri Lanoé, Ecole Normale Supérieure de Lyon, CNRS, Univ. de Lyon (France)
Olivier Maury, Ecole Normale Supérieure de Lyon, CNRS, Univ. de Lyon (France)
Sophie Marotte, INSERM, Univ. de Lyon (France)
Yann Leverrier, INSERM, Univ. de Lyon (France)
Patrice L. Baldeck, Lab. de Spectrométrie Physique, CNRS, Univ. Joseph Fourier (France)
Chantal Andraud, Ecole Normale Supérieure de Lyon, CNRS, Univ. de Lyon (France)


Published in SPIE Proceedings Vol. 8103:
Nanobiosystems: Processing, Characterization, and Applications IV
Norihisa Kobayashi; Fahima Ouchen; Ileana Rau, Editor(s)

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