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Proceedings Paper

Carbon nanotube-mediated siRNA delivery for gene silencing in cancer cells
Author(s): Tu Hong; Honglian Guo; Yaqiong Xu
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Paper Abstract

Small interfering RNA (siRNA) is potentially a promising tool in influencing gene expression with a high degree of target specificity. However, its poor intracellular uptake, instability in vivo, and non-specific immune stimulations impeded its effect in clinical applications. In this study, carbon nanotubes (CNTs) functionalized with two types of phospholipid-polyethylene glycol (PEG) have shown capabilities to stabilize siRNA in cell culture medium during the transfection and efficiently deliver siRNA into neuroblastoma and breast cancer cells. Moreover, the intrinsic optical properties of CNTs have been investigated through absorption and fluorescence measurements. We have found that the directly-functionalized groups play an important role on the fluorescence imaging of functionalized CNTs. The unique fluorescence imaging and high delivery efficiency make CNTs a promising material to deliver drugs and evaluate the treatment effect simultaneously.

Paper Details

Date Published: 12 September 2011
PDF: 7 pages
Proc. SPIE 8099, Biosensing and Nanomedicine IV, 80990H (12 September 2011); doi: 10.1117/12.894162
Show Author Affiliations
Tu Hong, Vanderbilt Univ. (United States)
Honglian Guo, Vanderbilt Univ. (United States)
Yaqiong Xu, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 8099:
Biosensing and Nanomedicine IV
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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