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Proceedings Paper

Controlled skeletal progenitor cell migration on nanostructured porous silicon/silicon micropatterns
Author(s): V. Torres-Costa; V. Sánchez-Vaquero; Á. Muñoz-Noval; L. González-Méndez; E. Punzón-Quijorna; D. Gallach-Pérez; M. Manso-Silván; G. Martínez-Muñoz; A. Climent-Font; J. P. García-Ruiz; R. J. Martín-Palma
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Paper Abstract

In this work nanostructured porous silicon (nanoPS) was used for the fabrication of surface micropatterns aiming at controlling cell adhesion and migration. In particular, surface patterns of nanoPS and Si were engineered by high-energy ion-beam irradiation and subsequent anodization. It was found that human skeletal progenitor cells are sensitive to oneand two-dimensional patterns and that focal adhesion is inhibited on nanoPS areas. In spite of this anti-fouling characteristics, studies on patterns with reduced Si areas show that cells conform to nanoPS pathways favoring migration through cell protrusion, body translocation and tail retraction from two parallel Si traction rails. Moreover, migration can be blocked and cells tend to arrange when grid patterns with the appropriate dimensions are fabricated. The experimental results confirm that progenitor cells are able to exploit nanoPS anti-fouling designs by adapting to it for migration purposes.

Paper Details

Date Published: 26 September 2011
PDF: 5 pages
Proc. SPIE 8104, Nanostructured Thin Films IV, 81040O (26 September 2011); doi: 10.1117/12.892705
Show Author Affiliations
V. Torres-Costa, Univ. Autónoma de Madrid (Spain)
V. Sánchez-Vaquero, Univ. Autónoma de Madrid (Spain)
Á. Muñoz-Noval, Univ. Autónoma de Madrid (Spain)
L. González-Méndez, Univ. Autónoma de Madrid (Spain)
E. Punzón-Quijorna, Univ. Autónoma de Madrid (Spain)
D. Gallach-Pérez, Univ. Autónoma de Madrid (Spain)
M. Manso-Silván, Univ. Autónoma de Madrid (Spain)
G. Martínez-Muñoz, Univ. Autónoma de Madrid (Spain)
A. Climent-Font, Univ. Autónoma de Madrid (Spain)
J. P. García-Ruiz, Univ. Autónoma de Madrid (Spain)
R. J. Martín-Palma, Univ. Autónoma de Madrid (Spain)

Published in SPIE Proceedings Vol. 8104:
Nanostructured Thin Films IV
Raúl J. Martín-Palma; Yi-Jun Jen; Tom G. Mackay, Editor(s)

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