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Proceedings Paper

Multi-modal optical diagnostic approach for non-invasive imaging of blood and lymphatic vascular networks in vivo
Author(s): Vyacheslav Kalchenko; Yuri Kuznetsov; Igor Meglinski; Alon Harmelin
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Paper Abstract

The use of multi-modal optical diagnostic approach has a great potential in medicine and biology allowing significantly expand the capabilities of vascular diagnostics. Multi-modal approach provides synchronic in vivo images of blood and lymph vessels. In current study the Dynamic Light Scattering approach has been used for rendering blood vessels structure and monitoring blood micro-flows in the mouse ear in vivo with the higher spatial resolution, whereas conventional Fluorescence Intravital Microscopy provides simultaneous image of lymphatic vessels. The results clearly demonstrate that combined application of Dynamic Light Scattering and conventional Fluorescence Intravital Microscopy approaches provides synchronic in vivo images of blood and lymph vessels as well as blood micro-flows with a high contrast and specificity.

Paper Details

Date Published: 21 March 2011
PDF: 4 pages
Proc. SPIE 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII, 799904 (21 March 2011); doi: 10.1117/12.890506
Show Author Affiliations
Vyacheslav Kalchenko, Weizmann Institute of Science (Israel)
Yuri Kuznetsov, Weizmann Institute of Science (Israel)
Igor Meglinski, Univ. of Otago (New Zealand)
Alon Harmelin, Weizmann Institute of Science (Israel)


Published in SPIE Proceedings Vol. 7999:
Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII
Valery V. Tuchin; Elina A. Genina, Editor(s)

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