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Proceedings Paper

Time-resolved and spectral-resolved optical imaging to study brain hemodynamics in songbirds
Author(s): Stéphane Mottin; Bruno Montcel; Hugues Guillet de Chatellus; Stéphane Ramstein; Clémentine Vignal; Nicolas Mathevon
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Paper Abstract

Contrary to the intense debate about brain oxygen dynamics and its uncoupling in mammals, very little is known in birds. In zebra finches, picosecond optical tomography (POT) with a white laser and a streak camera can measure in vivo oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb) concentration changes following physiological stimulation (familiar calls and songs). POT demonstrated sufficient sub-micromolar sensitivity to resolve the fast changes in hippocampus and auditory forebrain areas with 250 μm resolution. The time-course is composed of (i) an early 2s-long event with a significant decrease in Hb and HbO2, respectively -0.7 μMoles/L and -0.9 μMoles/L (ii) a subsequent increase in blood oxygen availability with a plateau of HbO2 (+0.3μMoles/L) and (iii) pronounced vasodilatation events immediately following the end of the stimulus. One of the findings of our work is the direct link between the blood oxygen level-dependent (BOLD) signals previously published in birds and our results. Furthermore, the early vasoconstriction event and post-stimulus ringing seem to be more pronounced in birds than in mammals. These results in bird, a tachymetabolic vertebrate with a long lifespan, can potentially yield new insights for example in brain aging.

Paper Details

Date Published: 14 June 2011
PDF: 6 pages
Proc. SPIE 8088, Diffuse Optical Imaging III, 80880C (14 June 2011); doi: 10.1117/12.889799
Show Author Affiliations
Stéphane Mottin, Lab. Hubert Curien, CNRS, Univ. de Lyon (France)
Bruno Montcel, CREATIS, CNRS, Univ. Lyon 1 (France)
Hugues Guillet de Chatellus, Lab. de spectrométrie physique, CNRS, Univ. de Grenoble (France)
Stéphane Ramstein, Lab. Hubert Curien, CNRS, Univ. de Lyon (France)
Clémentine Vignal, Ctr. de Neurosciences Paris-Sud, CNRS, Univ. Jean Monnet Saint-Etienne (France)
Nicolas Mathevon, Ctr. de Neurosciences Paris-Sud, CNRS, Univ. Jean Monnet Saint-Etienne (France)

Published in SPIE Proceedings Vol. 8088:
Diffuse Optical Imaging III
Andreas H. Hielscher; Paola Taroni, Editor(s)

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