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Proceedings Paper

Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography
Author(s): Hrebesh M. Subhash; Hui Xie; Jeffrey W. Smith; Owen McCarty
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Paper Abstract

Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA nanoparticles were prepared in 2% agarose solution. To study the feasibility of detecting the particles using PT-OCT, imaging was performed with a custom built PT-OCT system, and specific contrast was obtained with the prepared tissue mimicking phantoms. The excellent photo-thermal properties in combination with the positive tissue phantom results qualify the feasibility of dye-loaded PLGA particles as promising candidate for PT-OCT imaging applications.

Paper Details

Date Published: 17 June 2011
PDF: 4 pages
Proc. SPIE 8091, Optical Coherence Tomography and Coherence Techniques V, 809108 (17 June 2011); doi: 10.1117/12.889760
Show Author Affiliations
Hrebesh M. Subhash, Oregon Health and Science Univ. (United States)
Hui Xie, Sanford-Burnham Medical Research Institute (United States)
Jeffrey W. Smith, Sanford-Burnham Medical Research Institute (United States)
Owen McCarty, Oregon Health and Science Univ. (United States)

Published in SPIE Proceedings Vol. 8091:
Optical Coherence Tomography and Coherence Techniques V
Rainer A. Leitgeb; Brett E. Bouma, Editor(s)

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