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Proceedings Paper

Optical spectroscopy for quantitative sensing in human pancreatic tissues
Author(s): Robert H. Wilson; Malavika Chandra; William Lloyd; Leng-Chun Chen; James Scheiman; Diane Simeone; Barbara McKenna; Mary-Ann Mycek
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Paper Abstract

Pancreatic adenocarcinoma has a five-year survival rate of only 6%, largely because current diagnostic methods cannot reliably detect the disease in its early stages. Reflectance and fluorescence spectroscopies have the potential to provide quantitative, minimally-invasive means of distinguishing pancreatic adenocarcinoma from normal pancreatic tissue and chronic pancreatitis. The first collection of wavelength-resolved reflectance and fluorescence spectra and time-resolved fluorescence decay curves from human pancreatic tissues was acquired with clinically-compatible instrumentation. Mathematical models of reflectance and fluorescence extracted parameters related to tissue morphology and biochemistry that were statistically significant for distinguishing between pancreatic tissue types. These results suggest that optical spectroscopy has the potential to detect pancreatic disease in a clinical setting.

Paper Details

Date Published: 10 June 2011
PDF: 7 pages
Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 808713 (10 June 2011); doi: 10.1117/12.889724
Show Author Affiliations
Robert H. Wilson, Univ. of Michigan, Ann Arbor (United States)
Malavika Chandra, Univ. of Michigan, Ann Arbor (United States)
William Lloyd, Univ. of Michigan, Ann Arbor (United States)
Leng-Chun Chen, Univ. of Michigan, Ann Arbor (United States)
James Scheiman, Univ. of Michigan, Ann Arbor (United States)
Diane Simeone, Univ. of Michigan, Ann Arbor (United States)
Barbara McKenna, Univ. of Michigan, Ann Arbor (United States)
Mary-Ann Mycek, Univ. of Michigan, Ann Arbor (United States)


Published in SPIE Proceedings Vol. 8087:
Clinical and Biomedical Spectroscopy and Imaging II
Nirmala Ramanujam; Jürgen Popp, Editor(s)

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