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Proceedings Paper

Photoswitchable bactericidal effects from novel silica-coated silver nanoparticles
Author(s): Gustavo Fuertes; Esteban Pedrueza; Kamal Abderrafi; Rafael Abargues; Orlando Sánchez; Juan Martínez-Pastor; Jesús Salgado; Ernesto Jiménez
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Paper Abstract

The enhancement of the electromagnetic field in the surroundings of nanoparticles via surface plasmon resonance offers promising possibilities for biomedical applications. Here we report on the selective triggering of antibacterial activity using a new type of silver nanoparticles coated with silica, Ag@silica, irradiated at their surface plasmon frequency. The nanoparticles are able to bind readily to the surface of bacterial cells, although this does not affect bacterial growing since the silica shell largely attenuates the intrinsic toxicity of silver. However, upon simultaneous exposure to light corresponding to the absorption band of the nanoparticles, bacterial death is triggered selectively on the irradiated zone. Because of the low power density used in the treatments, we discard thermal effects as the cause of cell killing. Instead, we propose that the switched toxicity is due to the enhanced electromagnetic field in the proximity of the nanoparticles, which either directly (through membrane perturbation) or indirectly (through induced photochemical reactions) is able to cause cell death.

Paper Details

Date Published: 2 June 2011
PDF: 12 pages
Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 80921M (2 June 2011); doi: 10.1117/12.889675
Show Author Affiliations
Gustavo Fuertes, Univ. de València (Spain)
Esteban Pedrueza, Univ. de València (Spain)
Kamal Abderrafi, Univ. de València (Spain)
Rafael Abargues, Univ. de València (Spain)
Orlando Sánchez, Univ. de València (Spain)
Juan Martínez-Pastor, Univ. de València (Spain)
Jesús Salgado, Univ. de València (Spain)
Ernesto Jiménez, Univ. de València (Spain)


Published in SPIE Proceedings Vol. 8092:
Medical Laser Applications and Laser-Tissue Interactions V
Ronald Sroka; Lothar D. Lilge, Editor(s)

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