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Proceedings Paper

Poly(dimethylsiloxane) photonic microbioreactors and multiple internal reflection systems for real time cell screening
Author(s): Pedro Ortiz; Stefanie Demming; Elisabet Fernández-Rosas; Bergoi Ibarlucea; Jordi Vila-Planas; Stephanus Büttgenbach; Andreu Llobera
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Paper Abstract

In this paper two different photonic lab-on-a-chip devices for real-time cell screening are presented. We discuss, in parallel, screening of cell viability and cell count using a multiple total internal reflection (MIR) system, and a microbioreactor (MBR) for continuous cell culture screening. Each device takes advantage, in different ways, of the enhanced light-analyte interaction provided by the full-field approach. Their performance and how they represent an improvement to current methods, are also discussed herein. Both devices integrate photonic components and are fabricated by soft lithography (PDMS) replica molding of SU-8 masters, thus making them low-cost and easily mass produced.

Paper Details

Date Published: 5 May 2011
PDF: 13 pages
Proc. SPIE 8066, Smart Sensors, Actuators, and MEMS V, 80660D (5 May 2011); doi: 10.1117/12.889671
Show Author Affiliations
Pedro Ortiz, Ctr. Nacional de Microelectrónica (Spain)
Stefanie Demming, Univ. Autònoma de Barcelona (Spain)
Elisabet Fernández-Rosas, Technische Univ. Braunschweig (Germany)
Bergoi Ibarlucea, Ctr. Nacional de Microelectrónica (Spain)
Jordi Vila-Planas, Ctr. Nacional de Microelectrónica (Spain)
Stephanus Büttgenbach, Univ. Autònoma de Barcelona (Spain)
Andreu Llobera, Ctr. Nacional de Microelectrónica (Spain)
Univ. Autònoma de Barcelona (Spain)


Published in SPIE Proceedings Vol. 8066:
Smart Sensors, Actuators, and MEMS V
Ulrich Schmid; José Luis Sánchez-Rojas; Monika Leester-Schaedel, Editor(s)

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