Share Email Print
cover

Proceedings Paper

Discrimination of serum Raman spectroscopy between normal and colorectal cancer
Author(s): Xiaozhou Li; Tianyue Yang; Ting Yu; Siqi Li
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Raman spectroscopy of tissues has been widely studied for the diagnosis of various cancers, but biofluids were seldom used as the analyte because of the low concentration. Herein, serum of 30 normal people, 46 colon cancer, and 44 rectum cancer patients were measured Raman spectra and analyzed. The information of Raman peaks (intensity and width) and that of the fluorescence background (baseline function coefficients) were selected as parameters for statistical analysis. Principal component regression (PCR) and partial least square regression (PLSR) were used on the selected parameters separately to see the performance of the parameters. PCR performed better than PLSR in our spectral data. Then linear discriminant analysis (LDA) was used on the principal components (PCs) of the two regression method on the selected parameters, and a diagnostic accuracy of 88% and 83% were obtained. The conclusion is that the selected features can maintain the information of original spectra well and Raman spectroscopy of serum has the potential for the diagnosis of colorectal cancer.

Paper Details

Date Published: 15 June 2011
PDF: 5 pages
Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 808727 (15 June 2011); doi: 10.1117/12.889304
Show Author Affiliations
Xiaozhou Li, Shenyang Ligong Univ. (China)
Tianyue Yang, Shenyang Ligong Univ. (China)
Ting Yu, Karlsruhe Univ. of Applied Sciences (Germany)
Siqi Li, Solon High School (United States)


Published in SPIE Proceedings Vol. 8087:
Clinical and Biomedical Spectroscopy and Imaging II
Nirmala Ramanujam; Jürgen Popp, Editor(s)

© SPIE. Terms of Use
Back to Top