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Proceedings Paper

Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents
Author(s): Veronica Leautaud; Charles R. Horres; Vijayashree S. Bhattar; Michelle D. Williams; Ann M. Gillenwater; Rebecca R. Richards-Kortum
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Paper Abstract

Early detection is a potential key to improving the survival rates of oral cancer patients and reducing the morbidity associated with treatment. We seek to improve upon methods of detecting of early malignancies with oral brush biopsies by using immunofluorescence-based assessment of the expression of multiple well-described markers commonly overexpressed in oral cancers, such as Epidermal Growth Factor Receptor (EGFR) and Cytokeratin 8 (CK8). Furthermore, since abnormal cells are often scarce in brush biopsy samples, we seek to use magnetic microparticles targeted to these markers as a means of enriching the concentration of abnormal cells. Finally, we plan to conduct a small pilot study using these methods with brush biopsies from patients of the M. D. Anderson Cancer Center Head and Neck Clinic.

Paper Details

Date Published: 18 February 2011
PDF: 7 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832H (18 February 2011); doi: 10.1117/12.887755
Show Author Affiliations
Veronica Leautaud, Rice Univ. (United States)
Charles R. Horres, Rice Univ. (United States)
Vijayashree S. Bhattar, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Michelle D. Williams, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Ann M. Gillenwater, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Rebecca R. Richards-Kortum, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Bodo E. Knudsen; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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