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Proceedings Paper

Dynamic infrared imaging for biological and medical applications in Boron neutron capture therapy
Author(s): Gustavo A. Santa Cruz; Sara J. González; Alejandra Dagrosa; Amanda E. Schwint; Marina Carpano; Verónica A. Trivillin; Esteban F. Boggio; José Bertotti; Julio Marín; Andrea Monti Hughes; Ana J. Molinari; Miguel Albero
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Paper Abstract

Boron Neutron Capture Therapy (BNCT) is a treatment modality, currently focused on the treatment of cancer, which involves a tumor selective 10B compound and a specially tuned neutron beam to produce a lethal nuclear reaction. BNCT kills target cells with microscopic selectivity while sparing normal tissues from potentially lethal doses of radiation. In the context of the Argentine clinical and research BNCT projects at the National Atomic Energy Commission and in a strong collaboration with INVAP SE, we successfully implemented Dynamic Infrared Imaging (DIRI) in the clinical setting for the observation of cutaneous melanoma patients and included DIRI as a non invasive methodology in several research protocols involving small animals. We were able to characterize melanoma lesions in terms of temperature and temperature rate-of-recovery after applying a mild cold thermal stress, distinguishing melanoma from other skin pigmented lesions. We observed a spatial and temporal correlation between skin acute reactions after irradiation, the temperature pattern and the dose distribution. We studied temperature distribution as a function of tumor growth in mouse xenografts, observing a significant correlation between tumor temperature and drug uptake; we investigated temperature evolution in the limbs of Wistar rats for a protocol of induced rheumatoid arthritis (RA), DIRI being especially sensitive to RA induction even before the development of clinical signs and studied surface characteristics of tumors, precancerous and normal tissues in a model of oral cancer in the hamster cheek pouch.

Paper Details

Date Published: 10 May 2011
PDF: 18 pages
Proc. SPIE 8013, Thermosense: Thermal Infrared Applications XXXIII, 801307 (10 May 2011); doi: 10.1117/12.887359
Show Author Affiliations
Gustavo A. Santa Cruz, National Atomic Energy Commission (Argentina)
Sara J. González, National Atomic Energy Commission (Argentina)
National Research Council (Argentina)
Alejandra Dagrosa, National Research Council (Argentina)
National Atomic Energy Commission (Argentina)
Amanda E. Schwint, National Research Council (Argentina)
National Atomic Energy Commission (Argentina)
Marina Carpano, National Atomic Energy Commission (Argentina)
Verónica A. Trivillin, National Research Council (Argentina)
National Atomic Energy Commission (Argentina)
Esteban F. Boggio, National Atomic Energy Commission (Argentina)
José Bertotti, Favaloro Univ. (Argentina)
Julio Marín, National Atomic Energy Commission (Argentina)
Andrea Monti Hughes, National Atomic Energy Commission (Argentina)
Ana J. Molinari, National Atomic Energy Commission (Argentina)
Miguel Albero, INVAP SE (Argentina)

Published in SPIE Proceedings Vol. 8013:
Thermosense: Thermal Infrared Applications XXXIII
Morteza Safai; Jeff R. Brown, Editor(s)

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