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Proceedings Paper

Radiobiology with laser-accelerated quasi-monoenergetic proton beams
Author(s): A. Yogo; T. Maeda; T. Hori; H. Sakaki; K. Ogura; M. Nishiuchi; A. Sagisaka; P. R. Bolton; M. Murakami; S. Kawanishi; K. Kondo
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Paper Abstract

Human cancer cells are irradiated by laser-driven quasi-monoenergetic protons. Laser pulse intensities at the 5×1019-W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in-vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels up to 8 Gy, for which the single bunch does rate is 1 × 107 Gy/s and the effective dose rate is 0.2 Gy/s for 1-Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20 ± 0.11 using protons with a linear energy transfer of 17.1 ± 2.8 keV/μm.

Paper Details

Date Published: 26 May 2011
PDF: 8 pages
Proc. SPIE 8079, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles, 80791D (26 May 2011); doi: 10.1117/12.886680
Show Author Affiliations
A. Yogo, Japan Atomic Energy Agency (Japan)
T. Maeda, Japan Atomic Energy Agency (Japan)
Hyogo Ion Beam Medical Ctr. (Japan)
T. Hori, Japan Atomic Energy Agency (Japan)
H. Sakaki, Japan Atomic Energy Agency (Japan)
K. Ogura, Japan Atomic Energy Agency (Japan)
M. Nishiuchi, Japan Atomic Energy Agency (Japan)
A. Sagisaka, Japan Atomic Energy Agency (Japan)
P. R. Bolton, Japan Atomic Energy Agency (Japan)
M. Murakami, Hyogo Ion Beam Medical Ctr. (Japan)
S. Kawanishi, Japan Atomic Energy Agency (Japan)
K. Kondo, Japan Atomic Energy Agency (Japan)


Published in SPIE Proceedings Vol. 8079:
Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles
Wim P. Leemans; Eric Esarey; Simon M. Hooker; Kenneth W. D. Ledingham, Editor(s)

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