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Proceedings Paper

Compact intraoperative imaging device for sentinel lymph node mapping
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Paper Abstract

We have developed a novel real-time intraoperative fluorescence imaging device that can detect near-infrared (NIR) fluorescence and map sentinel lymph nodes (SLNs). In contrast to conventional imaging systems, this device is compact, portable, and battery-operated. It is also wearable and thus allows hands-free operation of clinicians. The system directly displays the fluorescence in its goggle eyepiece, eliminating the need for a remote monitor. Using this device in murine lymphatic mapping, the SLNs stained with indocyanine green (ICG) can be readily detected. Fluorescence-guided SLN resection under the new device was performed with ease. Ex vivo examination of resected tissues also revealed high fluorescence level in the SLNs. Histology further confirmed the lymphatic nature of the resected SLNs.

Paper Details

Date Published: 12 February 2011
PDF: 7 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100D (12 February 2011); doi: 10.1117/12.886226
Show Author Affiliations
Yang Liu, Washington Univ. in St. Louis (United States)
Adam Q. Bauer, Washington Univ. in St. Louis (United States)
Walter Akers, Washington Univ. in St. Louis (United States)
Gail Sudlow, Washington Univ. in St. Louis (United States)
Kexian Liang, Washington Univ. in St. Louis (United States)
Duanwen Shen, Washington Univ. in St. Louis (United States)
Mikhail Berezin, Washington Univ. in St. Louis (United States)
Joseph P. Culver, Washington Univ. in St. Louis (United States)
Samuel Achilefu, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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