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Proceedings Paper

Synthesis and biological studies of highly concentrated lisinopril-capped gold nanoparticles for CT tracking of angiotensin converting enzyme (ACE)
Author(s): William E. Ghann; Omer Aras; Thorsten Fleiter; Marie-Christine Daniel
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Paper Abstract

For patients with a history of heart attack or stroke, the prevention of another cardiovascular or cerebrovascular event is crucial. The development of cardiac and pulmonary fibrosis has been associated with overexpression of tissue angiotensin-converting enzyme (ACE). Recently, gold nanoparticles (GNPs) have shown great potential as X-ray computed tomography (CT) contrast agents. Since lisinopril is an ACE inhibitor, it has been used as coating on GNPs for targeted imaging of tissue ACE in prevention of fibrosis. Herein, lisinopril-capped gold nanoparticles (LIS-GNPs) were synthesized up to a concentration of 55 mgAu/mL. Their contrast was measured using CT and the results were compared to Omnipaque, a commonly used iodine-based contrast agent. The targeting ability of these LIS-GNPs was also assessed.

Paper Details

Date Published: 26 May 2011
PDF: 12 pages
Proc. SPIE 8025, Smart Biomedical and Physiological Sensor Technology VIII, 80250H (26 May 2011); doi: 10.1117/12.885526
Show Author Affiliations
William E. Ghann, Univ. of Maryland, Baltimore County (United States)
Omer Aras, Univ. of Maryland Medical Ctr. (United States)
Thorsten Fleiter, Univ. of Maryland Medical Ctr. (United States)
Marie-Christine Daniel, Univ. of Maryland, Baltimore County (United States)


Published in SPIE Proceedings Vol. 8025:
Smart Biomedical and Physiological Sensor Technology VIII
Brian M. Cullum; Eric S. McLamore, Editor(s)

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