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Proceedings Paper

Real-time smart fluorescence sensor platform
Author(s): Jason E. Dickens; Mike S. Vaughn; Mervin Taylor; Mike Ponstingl
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Paper Abstract

A novel compact LED array based light induced fluorescence (LIF) sensor has been developed for real-time in-line monitoring of intrinsic fluorophores in the solid and liquid state. The sensor is essential for on-the-spot, routine, and cost effective real-time analysis. The sensor is designed to provide real-time emission response along with various smart sensing parameters to ensure real-time measurement quality that is required for regulated GMP process monitoring applications. This work describes a LIF sensor tailored for solid-phase fluorometry. Fundamental figures of merit, excitation overexposure and smart sensing features required for modern process monitoring and control are discussed within the context of pharmaceutical solid-phase manufacturing and similar applications.

Paper Details

Date Published: 12 May 2011
PDF: 9 pages
Proc. SPIE 8032, Next-Generation Spectroscopic Technologies IV, 80320S (12 May 2011); doi: 10.1117/12.884533
Show Author Affiliations
Jason E. Dickens, GlaxoSmithKline (United States)
Mike S. Vaughn, GlaxoSmithKline (United States)
Mervin Taylor, GlaxoSmithKline (United States)
Mike Ponstingl, Custom Sensors and Technology (United States)

Published in SPIE Proceedings Vol. 8032:
Next-Generation Spectroscopic Technologies IV
Mark A. Druy; Richard A. Crocombe, Editor(s)

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