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Proceedings Paper

Test of a novel miniature blood pressure sensor in the coronary arteries of a swine model
Author(s): Nan Wu; Kai Sun; Xiaotian Zou; Kurt Barringhaus; Xingwei Wang
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Paper Abstract

Fractional flow reserve (FFR) has proven to be very useful in diagnosis of narrowed coronary arteries. It is a technique that is used in coronary catheterization to measure blood pressure difference across a coronary artery stenosis in maximal flow. In-vivo blood pressure measurement is critical in FFR diagnosis. This paper presents a novel miniature all-optical fiber blood pressure sensor. It is based on Fabry-Perot (FP) interferometry principle. The FP cavity was fabricated by directly wet etching the fiber tip. Then, a diaphragm with well-controlled thickness was bonded to the end face of the fiber using the thermal bonding technique. Finally, the sensor was packaged with a bio-compatible and flexible coil for animal tests. A 25-50 kg Yorkshire swine model was introduced as the animal test target. The left anterior descending coronary artery (LAD) was exposed, and beyond the takeoff of the largest diagonal branch, a 3.0 mm vascular occluder was secured. Firstly, standard invasive manometry was used to obtain the blood pressure as baseline. Next, a guiding catheter was introduced into the ostium of the left main coronary artery, and the miniature blood pressure sensor was advanced into the LAD at a point beyond the vascular occlude. The blood pressure beyond the vascular occlude was recorded. The sensor successfully recorded the blood pressure at both near-end and far-end of the vascular occluder.

Paper Details

Date Published: 2 June 2011
PDF: 6 pages
Proc. SPIE 8028, Fiber Optic Sensors and Applications VIII, 80280N (2 June 2011); doi: 10.1117/12.884273
Show Author Affiliations
Nan Wu, Univ. of Massachusetts Lowell (United States)
Kai Sun, Univ. of Massachusetts Lowell (United States)
Xiaotian Zou, Univ. of Massachusetts Lowell (United States)
Kurt Barringhaus, Univ. of Massachusetts Medical School (United States)
Xingwei Wang, Univ. of Massachusetts Lowell (United States)

Published in SPIE Proceedings Vol. 8028:
Fiber Optic Sensors and Applications VIII
Stephen J. Mihailov; Henry H. Du; Gary Pickrell, Editor(s)

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