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Proceedings Paper

Identification of biological agents using surface enhanced Raman scattering
Author(s): Tracy L. Paxon; R. Scott Duthie; Casey Renko; Andrew A. Burns; Marie L. Lesaicherre; Frank J. Mondello
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Paper Abstract

GE Global Research Center, in collaboration with Morpho Detection, Inc. has developed an assay scheme for the identification of biological agents using Surface Enhanced Raman Scattering (SERS). Specifically, unique spectroscopic signatures are generated using SERS tags consisting of individual glass-encapsulated gold nanoparticles and surfacebound reporter molecules. These SERS tags are modified with a capture moiety specific to the antigen of interest, and serve as a spectroscopic label in a bead-based sandwich assay. Assays are being developed for a variety of pathogens and this paper will focus on aspects of assay development, optimization, stabilization and validation. Results on the development of an assay to detect Ricin toxin will be presented, and preliminary feasibility studies for the detection of additional pathogens will be discussed.

Paper Details

Date Published: 13 May 2011
PDF: 11 pages
Proc. SPIE 8034, Photonic Microdevices/Microstructures for Sensing III, 803403 (13 May 2011); doi: 10.1117/12.884259
Show Author Affiliations
Tracy L. Paxon, GE Global Research (United States)
R. Scott Duthie, GE Global Research (United States)
Casey Renko, GE Global Research (United States)
Andrew A. Burns, GE Global Research (United States)
Marie L. Lesaicherre, Morpho Detection Inc. (United States)
Frank J. Mondello, GE Global Research (United States)

Published in SPIE Proceedings Vol. 8034:
Photonic Microdevices/Microstructures for Sensing III
Hai Xiao; Xudong Fan; Anbo Wang, Editor(s)

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