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Proceedings Paper

Integrated photonic structures for parallel fluorescence and refractive index biosensing
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Paper Abstract

We present a multi-modality optical sensing platform employing integrated Vertical Cavity Surface Emitting Lasers (VCSELs), photodetectors, and filters suitable for portable, real-time analyte detection in aqueous environments. Fluorescence and refractive index sensors designed to utilize visible and near-infrared VCSELs for low background absorption from analyte delivery fluids are described. We demonstrate in vitro fluorescence sensing of Cy5.5 dye with a detection sensitivity of 5 nM and photonic crystal slab refractive index sensing with tunable GaAs-based 670 nm VCSELs. This compact, parallel sensor architecture enables multiplexed, cost-effective on-chip biosensing.

Paper Details

Date Published: 14 May 2011
PDF: 13 pages
Proc. SPIE 8034, Photonic Microdevices/Microstructures for Sensing III, 803406 (14 May 2011); doi: 10.1117/12.884228
Show Author Affiliations
Meredith M. Lee, Stanford Univ. (United States)
Thomas D. O'Sullivan, Stanford Univ. (United States)
Antonio Cerruto, Stanford Univ. (United States)
Victor Liu, Stanford Univ. (United States)
Jingyu Zhang, The Univ. of New Mexico (United States)
Ofer Levi, Univ. of Toronto (Canada)
Heon Lee, Korea Univ. (Korea, Republic of)
Steven R. J. Brueck, The Univ. of New Mexico (United States)
Shanhui Fan, Stanford Univ. (United States)
James S. Harris, Stanford Univ. (United States)


Published in SPIE Proceedings Vol. 8034:
Photonic Microdevices/Microstructures for Sensing III
Hai Xiao; Xudong Fan; Anbo Wang, Editor(s)

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