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Proceedings Paper

Optical path of infrared neural stimulation in the guinea pig and cat cochlea
Author(s): Suhrud M. Rajguru; Margaret Hwang; Laura E. Moreno; Agnella I. Matic; Stuart R. Stock; Claus-Peter Richter
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Paper Abstract

It has been demonstrated previously that infrared neural stimulation (INS) can be used to stimulate spiral ganglion cells in the cochlea. With INS, neural stimulation can be achieved without direct contact of the radiation source and the tissue and is spatially well resolved. The presence of fluids or bone between the target structure and the radiation source may lead to absorption or scattering of the radiation and limit the efficacy of INS. To develop INS based cochlear implants, it is critical to determine the beam path of the radiation in the cochlea. In the present study, we utilized noninvasive X-ray microtomography (microCT) to visualize the orientation and location of the optical fiber within the guinea pig and cat cochlea. Overall, the results indicated that the optical fiber was directed towards the spiral ganglion cells in the cochlea and not the nerve fibers in the center of the modiolus. The fiber was approximately 300 μm away from the target structures. In future studies, results from the microCT will be correlated with physiology obtained from recordings in the midbrain.

Paper Details

Date Published: 18 February 2011
PDF: 8 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788357 (18 February 2011); doi: 10.1117/12.883219
Show Author Affiliations
Suhrud M. Rajguru, Northwestern Feinberg School of Medicine (United States)
Margaret Hwang, Northwestern Feinberg School of Medicine (United States)
Laura E. Moreno, Northwestern Feinberg School of Medicine (United States)
Agnella I. Matic, Northwestern Feinberg School of Medicine (United States)
Stuart R. Stock, Northwestern Feinberg School of Medicine (United States)
Claus-Peter Richter, Northwestern Feinberg School of Medicine (United States)
Northwestern Univ. (United States)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Bodo E. Knudsen; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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