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Proceedings Paper

Terahertz time-lapse imaging of hydration in physiological tissues
Author(s): David B. Bennett; Zachary D. Taylor; Neha Bajwa; Priyamvada Tewari; Ashkan Maccabi; Shijun Sung; Rahul S. Singh; Martin O. Culjat; Warren S. Grundfest; Elliott R. Brown
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Paper Abstract

This study describes terahertz (THz) imaging of hydration changes in physiological tissues with high water concentration sensitivity. A fast-scanning, pulsed THz imaging system (centered at 525 GHz; 125 GHz bandwidth) was utilized to acquire a 35 mm x 35 mm field-of-view with 0.5 mm x 0.5 mm pixels in less than two minutes. THz time-lapsed images were taken on three sample systems: (1) a simple binary system of water evaporating from a polypropylene towel, (2) the accumulation of fluid at the site of a sulfuric acid burn on ex vivo porcine skin, and (3) the evaporative dehydration of an ex vivo porcine cornea. The diffusion-regulating behavior of corneal tissue is elucidated, and the correlation of THz reflectivity with tissue hydration is measured using THz spectroscopy on four ex vivo corneas. We conclude that THz imaging can discern small differences in the distribution of water in physiological tissues and is a good candidate for burn and corneal imaging.

Paper Details

Date Published: 23 February 2011
PDF: 8 pages
Proc. SPIE 7938, Terahertz Technology and Applications IV, 793808 (23 February 2011); doi: 10.1117/12.882962
Show Author Affiliations
David B. Bennett, Univ. of California, Los Angeles (United States)
Zachary D. Taylor, Univ. of California, Los Angeles (United States)
Neha Bajwa, Univ. of California, Los Angeles (United States)
Priyamvada Tewari, Univ. of California, Los Angeles (United States)
Ashkan Maccabi, Univ. of California, Los Angeles (United States)
Shijun Sung, Univ. of California, Los Angeles (United States)
Rahul S. Singh, Univ. of California, Los Angeles (United States)
Univ. of California, Santa Barbara (United States)
Martin O. Culjat, Univ. of California, Los Angeles (United States)
Univ. of California, Santa Barbara (United States)
Warren S. Grundfest, Univ. of California, Los Angeles (United States)
Elliott R. Brown, Wright State Univ. (United States)


Published in SPIE Proceedings Vol. 7938:
Terahertz Technology and Applications IV
Laurence P. Sadwick; Créidhe M. M. O'Sullivan, Editor(s)

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