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Proceedings Paper

Enhanced transfection of brain tumor suppressor genes by photochemical internalization
Author(s): Chih H. Chou; Chung-Ho Sun; Yi-Hong Zhou; Steen J. Madsen; Henry Hirschberg
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Paper Abstract

One of many limitations for cancer gene therapy is the inability of the therapeutic gene to transfect a sufficient number of tumor cells. Photochemical internalization (PCI) is a photodynamic therapy-based approach for improving the delivery of macromolecules and genes into the cell cytosol. The utility of PCI for the delivery of a tumor suppressor gene (PAX-6) was investigated in monolayers and spheroids consisting of F98 rat glioma cells.

Paper Details

Date Published: 17 February 2011
PDF: 9 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832D (17 February 2011); doi: 10.1117/12.882954
Show Author Affiliations
Chih H. Chou, Beckman Laser Institute and Medical Clinic (United States)
Chung-Ho Sun, Beckman Laser Institute and Medical Clinic (United States)
Yi-Hong Zhou, Univ. of California, Irvine (United States)
Steen J. Madsen, Univ. of Nevada, Las Vegas (United States)
Henry Hirschberg, Beckman Laser Institute and Medical Clinic (United States)
Univ. of Nevada, Las Vegas (United States)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Bodo E. Knudsen; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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