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Proceedings Paper

Phase contrast imaging of cochlear soft tissue
Author(s): Stephanie Shintani Smith; Margaret Hwang; Christoph Rau; Andrew J. Fishman; Wah-Keat Lee; Claus-Peter Richter
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Paper Abstract

A noninvasive technique to image soft tissue could expedite diagnosis and disease management in the auditory system. We propose inline phase contrast imaging with hard X-rays as a novel method that overcomes the limitations of conventional absorption radiography for imaging soft tissue. In this study, phase contrast imaging of mouse cochleae was performed at the Argonne National Laboratory Advanced Photon Source. The phase contrast tomographic reconstructions show soft tissue structures of the cochlea, including the inner pillar cells, the inner spiral sulcus, the tectorial membrane, the basilar membrane, and the Reissner's membrane. The results suggest that phase contrast X-ray imaging and tomographic techniques hold promise to noninvasively image cochlear structures at an unprecedented cellular level.

Paper Details

Date Published: 17 February 2011
PDF: 4 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788323 (17 February 2011); doi: 10.1117/12.882949
Show Author Affiliations
Stephanie Shintani Smith, Northwestern Univ. Feinberg School of Medicine (United States)
Margaret Hwang, Northwestern Univ. Feinberg School of Medicine (United States)
Christoph Rau, Northwestern Univ. Feinberg School of Medicine (United States)
Diamond Light Source Ltd. (United Kingdom)
Andrew J. Fishman, Northwestern Univ. Feinberg School of Medicine (United States)
Northwestern Univ. (United States)
Wah-Keat Lee, Argonne National Lab. (United States)
Claus-Peter Richter, Northwestern Univ. Feinberg School of Medicine (United States)
Northwestern Univ. (United States)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory M.D.; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg M.D.; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong M.D.; Justus F. R. Ilgner M.D.; Bodo E. Knudsen M.D.; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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