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Proceedings Paper

Selective vapor phase sensing of small molecules using biofunctionalized field effect transistors
Author(s): Joshua A. Hagen; Sang Nyon Kim; Nancy Kelley-Loughnane; Rajesh R. Naik; Morley O. Stone
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Paper Abstract

This work details a proof of concept study for vapor phase selective sensing using a strategy of biorecognition elements (BRE) integrated into a zinc oxide field effect transistor (ZnO FET). ZnO FETs are highly sensitive to changes to the environment with little to no selectivity. Addition of a biorecognition element retains the sensitivity of the device while adding selectivity. The DNA aptamer designed to bind the small molecule riboflavin was covalently integrated into the ZnO FET and detects the presence of 116 ppb of riboflavin in a nitrogen atmosphere by a change in current. The unfunctionalized ZnO FET shows no response to this same concentrations of riboflavin, showing that the aptamerbinding strategy may be a promising strategy for vapor phase sensing.

Paper Details

Date Published: 3 June 2011
PDF: 7 pages
Proc. SPIE 8018, Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII, 80180B (3 June 2011); doi: 10.1117/12.882119
Show Author Affiliations
Joshua A. Hagen, Air Force Research Lab. (United States)
Sang Nyon Kim, Air Force Research Lab. (United States)
Nancy Kelley-Loughnane, Air Force Research Lab. (United States)
Rajesh R. Naik, Air Force Research Lab. (United States)
Morley O. Stone, Air Force Research Lab. (United States)


Published in SPIE Proceedings Vol. 8018:
Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XII
Augustus W. Fountain; Patrick J. Gardner, Editor(s)

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